Focused Ultrasonic Homogenizer

Focused Ultrasonic Generator

The focused ultrasonic generator efficiently and precisely delivers ultrasonic energy in a highly adjustable manner, enabling programmable control over the energy density of acoustic pulses transmitted to the sample. This modulation of acoustic properties allows for control over particle size and shape formation. With exceptional stability, the focused ultrasonic generator ensures reproducible formulation processes.

Features of Focused Ultrasonic Homogenizer
✓ Constructed with passivated 316 stainless steel
✓ Explosion-proof modular design (stainless steel drip-proof enclosure)
✓ Ensures 100% complete sample containment
✓ Superior sample temperature control performance
✓ Future compliance with cGMP production standards

Flow-Through Processing Vessel Overview
• Fluid-contact surfaces made of electropolished 316 stainless steel
• High heat flux heat exchanger with Dean vortex cooling design
• Sample temperature control range: 4–40°C
• Inlet/outlet temperature monitoring
• All fluid-contact surfaces constructed of 316 stainless steel

Thermocouple
• In-line temperature measurement for real-time sample monitoring

Product Applications

Formulation & Drug Delivery Applications
Micronization Technology
• Enhanced bioavailability
• Significant reduction of API degradation during solubility screening
• Standardized and automated reproducible protocols

AFA Technology Accelerates Transition to First-in-Human Trials

Liposomes
• Emulsions
• AFA Nanoparticles
• Co-solvent Free

• Enables preparation of lipid or hydrophobic compound formulations without organic solvents
  • Thermal Damage Free

• Formulation preparation achievable at low temperatures (e.g., 4°C)
  • Contamination Free

• Preparation conducted in closed, sterile, single-use containers
  • Non-contact Processing

• Achieves 100% total recovery of rare and expensive materials

Nano-suspensions
"Top-down" milling approach
"Bottom-up" crystallization method
• Enables early toxicology studies with limited material

• 100% material recovery

• Processed in sterile, contamination-free containers
  • Achieves industry-leading particle size levels

• Zero risk of grinding bead contamination
  • Accelerates dose-range exploration studies

• Significantly reduces time and material consumption in complex formulation development

Unique Delivery Systems & Intravenous Injectables

Dissolution Applications
• Resuspension of settled formulations
• Enhanced solvent/solute interactions in molecular boundary layers
• Significantly improved dissolution rates
• Automated compound resuspension in high-throughput screening

Crystallization Process Comparison
• Accelerated nucleation with reduced induction time
• Polymorph preservation
• Controlled particle size distribution